@article{JTD10617,
author = {Michael C. Reade},
title = {Low dose dexmedetomidine for the prophylaxis of perioperative ICU delirium—how much evidence is enough?},
journal = {Journal of Thoracic Disease},
volume = {8},
number = {11},
year = {2016},
keywords = {},
abstract = {Few clinical trials in critical care medicine suggest clinicians should do something most would not have previously considered. The recently published randomised, placebo-controlled, 2-hospital blinded study of low dose, non-titrated dexmedetomidine in 700 elective surgical patients >65 years old admitted to an intensive care unit in the immediate postoperative period (1) is such a trial. Su et al. showed dexmedetomidine 0.1 mcg/kg/hr (a very low dose, well below that used for sedation in most patients) from the time of ICU admission to 8 am on the first postoperative day was associated with a reduction in the incidence of postoperative delirium of >50% (from 23% to 9%, P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/10617}
}