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Correlation of matrix metalloproteinase-2 and -9 expression with recurrences in primary spontaneous pneumothorax patients

   
@article{JTD11275,
	author = {Wen-Chin Chiu and Yi-Chen Lee and Yu-Han Su and Chee-Yin Chai and Stephen Chu-Sung Hu and Shyng-Shiou F. Yuan and Shah-Hwa Chou},
	title = {Correlation of matrix metalloproteinase-2 and -9 expression with recurrences in primary spontaneous pneumothorax patients},
	journal = {Journal of Thoracic Disease},
	volume = {8},
	number = {12},
	year = {2016},
	keywords = {},
	abstract = {Background: Primary spontaneous pneumothorax (PSP) is a common benign disorder. However, unpredictable recurrence is a major concern for most patients. The aim of the present study was to assess the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in alveolar macrophages of patients with PSP and its relationship with recurrence.
Methods: Ninety-two patients who received needlescopic video-assisted thoracoscopic surgery (NVATS) wedge resection of lung with identifiable blebs for PSP were enrolled for the study. Immunohistochemistry was performed to evaluate the expression of MMP-2 and MMP-9 in lung tissues of patients with PSP. The result was correlated with clinicopathological variables and recurrence rates by the chi-square test. The value of MMP-2 and MMP-9 for overall recurrence was evaluated by univariate and multivariable Cox regression analyses.
Results: The MMP-2 and MMP-9 staining was predominantly observed in alveolar macrophages of patients with PSP. We found that MMP-2 (recurrence: P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/11275}
}