@article{JTD11632,
author = {Chao Zhang and Haitang Yang and Heng Zhao and Baoping Lang and Xiangdong Yu and Peng Xiao and Xiao Zhang},
title = {Clinical outcomes of surgically resected combined small cell lung cancer: a two-institutional experience},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {1},
year = {2017},
keywords = {},
abstract = {Background: The combined small cell lung cancer (c-SCLC) was rare and its clinicopathological characteristics had not been thoroughly described. The aim of this study was to determine prognostic factors and survival in c-SCLC patients.
Methods: Clinical records of patients with c-SCLC who underwent surgery between January 2009 and December 2013 in two institutions were retrospectively reviewed.
Results: Ninety-seven patients were identified. The most common pathology was combined SCLC and large cell neuroendocrine carcinoma (LCNEC, N=46), followed by combined SCLC and squamous cell carcinoma (SCC) (N=32), combined SCLC and adenocarcinoma (AC) (N=12), and combined SCLC and adenosquamous carcinoma (ASC) (N=7). The overall survival (OS) rates of the entire cohort were 42.4% and 35.2% at 3 and 5 years, respectively. Multivariate analysis identified sex [female vs. male, hazards ratio (HR) =0.38; 95% confidence interval (CI): 0.19–0.79; P=0.010], age (53 years, HR =0.28; 95% CI: 0.09–0.81; P=0.019), performance status (2, HR =0.08; 95% CI: 0.02–0.32; P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/11632}
}