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LEF1/NFE2L3/TACC1 axis activates the AKT-mTOR pathway to promote the progression of esophageal squamous cell carcinoma

   
@article{JTD116793,
	author = {Hao Li and Shengming Xu and Ning Li and Tongyi Xu and Tao Li and Hezhong Chen and Qijue Lu},
	title = {LEF1/NFE2L3/TACC1 axis activates the AKT-mTOR pathway to promote the progression of esophageal squamous cell carcinoma},
	journal = {Journal of Thoracic Disease},
	volume = {18},
	number = {4},
	year = {2026},
	keywords = {},
	abstract = {Esophageal squamous cell carcinoma (ESCC) has a poor prognosis, with a 5-year survival rate below 20%, due to high recurrence and metastasis. Lymphoid enhancer-binding factor 1 (LEF1) promotes ESCC progression via epithelial-mesenchymal transition (EMT) and stemness, but its downstream transcriptional targets remain unclear. This study aimed to identify novel therapeutic targets by elucidating the LEF1-mediated regulatory network in ESCC.},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/116793}
}