@article{JTD12155,
author = {Wen-Liang Guo and Zi-Qing Zhou and Lu Chen and Zhu-Quan Su and Chang-Hao Zhong and Yu Chen and Shi-Yue Li},
title = {Serum KL-6 in pulmonary alveolar proteinosis: China compared historically with Germany and Japan},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {2},
year = {2017},
keywords = {},
abstract = {Background: KL-6 is a biomarker of the severity of pulmonary alveolar proteinosis (PAP). We noticed a significant difference in the mean serum KL-6 level between Japanese and Caucasian patients. To assess the clinical value of serum KL-6 in Chinese PAP patients, and to compare the differences in serum KL-6 levels in Chinese patients and patients of other ethnicities.
Methods: From 2014–2016, we prospectively examined 37 Chinese Han patients with PAP, measured their serum KL-6 levels, evaluated the correlation between initial KL-6 levels and clinical variables, and compared our results with studies from Japan and Germany (similar methods were used). We searched dbSNP for the MUC1 568 (rs4072037) genotype or allele frequency distributions in China, Japan, and Germany.
Results: Initial serum KL-6 levels were significantly correlated with baseline PaO2, A-aDO2, DLCO, FVC, and LDH levels (all P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/12155}
}