@article{JTD125647,
author = {Xiaoyu Zhen and Li Tu and Hong Xie and Yuting Wu and Shi Zhou and Xuehua Shen and Yushi Yang and Xiaowan Guo},
title = {Pulmonary sclerosing pneumocytoma demonstrated heterogeneous tumor growth rate on serial CT: a retrospective cohort study},
journal = {Journal of Thoracic Disease},
volume = {0},
number = {0},
year = {2026},
keywords = {},
abstract = {Background: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor with various manifestations, posing a challenge for accurate diagnosis and appropriate management. Imaging, particularly computed tomography (CT), is crucial for the diagnosis of PSP, and imaging surveillance is adopted as a strategy for the management of PSP patients. However, the natural history and growth patterns of PSP remain poorly characterized, creating an urgent need for evidence-based surveillance protocols to guide clinical management. This study aimed to investigate the CT manifestations and tumor growth patterns of PSP to enhance understanding and provide evidence for the clinical management of PSP patients.Methods: A retrospective observational cohort study was conducted among PSP patients diagnosed between January 2014 and October 2025 at a single tertiary hospital in southwestern China. Inclusion criteria were: (I) histopathologically diagnosed PSP registered in the pathology information system; (II) available preoperative chest CT; and (III) complete clinical records. Exclusion criteria included: (I) incorrect diagnosis of PSP; (II) incomplete CT data or CT of poor quality; and (III) prior lung surgery or malignancy affecting follow-up assessment. Baseline clinical factors (age, sex, symptoms, smoking history) and CT features (size, location, morphology, calcification, enhancement patterns) were systematically recorded. For 17 patients with serial CT scans, tumor volume doubling time (TVDT) was calculated using the modified Schwartz formula. Growth patterns were classified as stable or no growth [volume doubling time (VDT) >6,000 days], slow or indolent (600–6,000 days), and rapid (},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/125647}
}