@article{JTD12754,
author = {Francesco Sturla and Francesco Onorati and Giovanni Puppini and Omar A. Pappalardo and Matteo Selmi and Emiliano Votta and Giuseppe Faggian and Alberto Redaelli},
title = {Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {Suppl 4},
year = {2017},
keywords = {},
abstract = {Background: Accurate quantification of mitral valve (MV) morphology and dynamic behavior over the cardiac cycle is crucial to understand the mechanisms of degenerative MV dysfunction and to guide the surgical intervention. Cardiac magnetic resonance (CMR) imaging has progressively been adopted to evaluate MV pathophysiology, although a dedicated framework is required to perform a quantitative assessment of the functional MV anatomy.
Methods: We investigated MV dynamic behavior in subjects with normal MV anatomy (n=10) and patients referred to surgery due to degenerative MV prolapse, classified as fibro-elastic deficiency (FED, n=9) and Barlow’s disease (BD, n=10). A CMR-dedicated framework was adopted to evaluate prolapse height and volume and quantitatively assess valvular morphology and papillary muscles (PAPs) function over the cardiac cycle. Multiple comparison was used to investigate the hallmarks associated to MV degenerative prolapse and evaluate the feasibility of anatomical and functional distinction between FED and BD phenotypes.
Results: On average, annular dimensions were significantly (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/12754}
}