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What is the optimal first-line treatment for advanced anaplastic lymphoma kinase-rearranged non-small cell lung cancer?

   
@article{JTD13282,
	author = {Ikuo Sekine},
	title = {What is the optimal first-line treatment for advanced anaplastic lymphoma kinase-rearranged non-small cell lung cancer?},
	journal = {Journal of Thoracic Disease},
	volume = {9},
	number = {5},
	year = {2017},
	keywords = {},
	abstract = {Anaplastic lymphoma kinase (ALK)-gene rearrangements work as an oncogenic driver in 3–8% of patients with non-small cell lung cancer (NSCLC) (1,2). These patients tend to be younger than those without driver mutations, and have no or little smoking history. ALK-rearranged tumors are usually adenocarcinomas, frequently with an acinar-predominant structure (3). In general, ALK rearrangements are mutually exclusive of other activating mutations such as epidermal growth factor receptor (EGFR) and KRAS mutations (2).},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/13282}
}