@article{JTD1424,
author = {Lei Pan and Yong-Zhong Guo and Bo Zhang and Jun-Hong Yan},
title = {Does roflumilast improve dyspnea in patients with chronic obstructive pulmonary disease? A meta-analysis},
journal = {Journal of Thoracic Disease},
volume = {5},
number = {4},
year = {2013},
keywords = {},
abstract = {Introduction: Although several large studies showed roflumilast (Rof) has demonstrated efficacy in patients with chronic obstructive pulmonary disease (COPD), the efficacy of Rof in dyspnea remains unclear. We therefore undertook a meta-analysis to assess the efficacy of Rof in dyspnea for COPD patients.
Methods: A computerized search through electronic databases was performed to obtain randomized controlled trials (RCTs). Dyspnea was assessed by the transition dyspnea index (TDI) and the UCSD Shortness of Breath Questionnaire (SOBQ). The quality of the included studies was assessed by the Jadad score. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated and heterogeneity was assessed with the I2 test. The effect sizes were compared with the minimum clinically important difference (MCID).
Results: Four RCTs involving 4,767 patients with forced expiratory volume in one second (FEV1) },
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/1424}
}