@article{JTD15475,
author = {Wen-Jing Ye and Wei-Guo Xu and Xue-Jun Guo and Feng-Feng Han and Juan Peng and Xiao-Ming Li and Wen-Bin Guan and Li-Wei Yu and Jin-Yuan Su and Zhi-Lei Cui and Lin Song and Yue Zhang and Yan-Min Wang and Tian-Yun Yang and Xia-Hui Ge and Di Yao and Song Liu},
title = {Differences in airway remodeling and airway inflammation among moderate-severe asthma clinical phenotypes},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {9},
year = {2017},
keywords = {},
abstract = {Background: To identify asthma clinical phenotypes using cluster analysis and improve our understanding of heterogeneity in asthma.
Methods: Clustering approaches were applied to 203 patients who were diagnosed with asthma in XinHua Hospital (January 2012 to December 2015). One hundred and twenty patients underwent multi-slice spiral computed tomography (MSCT) examination and 30 underwent bronchial mucosal biopsy for evaluation of airway remodeling and airway inflammation among the phenotypes.
Results: Four groups were identified. Patients in cluster 1 (n=52) had early onset atopic asthma and patients in cluster 2 (n=65) had small airway obstruction and atopic asthma. Cluster 3 (n=52) was a unique group of patients with late-onset and non-atopic asthma. Patients in cluster 4 (n=34) had severe airflow obstruction and obvious airway remodeling as observed on MSCT (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/15475}
}