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Five reasons for caution in advocating low-dose computerized tomographic lung cancer screening

   
@article{JTD15520,
	author = {Jerome Reich and Jong Kim},
	title = {Five reasons for caution in advocating low-dose computerized  tomographic lung cancer screening},
	journal = {Journal of Thoracic Disease},
	volume = {9},
	number = {9},
	year = {2017},
	keywords = {},
	abstract = {The 53.5K-person, low-dose computerized tomographic (LDCT), National Lung Cancer Screening Trial (NLST) achieved a 20% reduction in lung cancer mortality and a 6.7% reduction in all-cause mortality at 6.5-year median follow-up. Failure of European LDCT trials employing null (i.e., unscreened) controls to reproduce this benefit compels caution in adopting a policy of population screening. Additional concerns merit attention: surgical mortality is not trivial; overdiagnosis is substantial; disease-free life expectancy and quality of life are markedly diminished by loss of pulmonary reserve; the combination of overdiagnosis and diminished disease-free life expectancy is pernicious.},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/15520}
}