@article{JTD15730,
author = {David N. Ranney and Michael S. Mulvihill and Babatunde A. Yerokun and Matthew G. Hartwig},
title = {Esophageal resection after neoadjuvant therapy: understanding the limitations of large database analyses},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {10},
year = {2017},
keywords = {},
abstract = {Determining the optimal timing of surgical resection for esophageal adenocarcinoma following neoadjuvant therapy has proven to be a challenging task, and the clinical implications for patients undergoing surgery at various time intervals remain elusive. In an effort to fill a gap in the current retrospective literature pertaining to this clinical question, we utilized the method of restricted cubic splines (RCS) to investigate the balance in this timing from a unique statistical perspective. Using the National Cancer Database (NCDB), we determined an inflection point of 56 days wherein an increased incidence of pathologic complete response was balanced with a decreased rate of overall survival (1).},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/15730}
}