TY  - JOUR
AU  - Casha, Aaron R.
AU  - Camilleri, Liberato
AU  - Manché, Alexander
AU  - Gatt, Ruben
AU  - Gauci, Marilyn
AU  - Camilleri-Podesta, Marie-Therese
AU  - Grima, Joseph N.
AU  - Scarci, Marco
AU  - Chetcuti, Stanley
PY  - 2017
TI  - Physiological rules for the heart, lungs and other pressure-based organs
JF  - Journal of Thoracic Disease; Vol 9, No 10 (October 31, 2017): Journal of Thoracic Disease
Y2  - 2017
KW  - 
N2  - Background: The adherence of the heart to physical laws, such as Laplace’s Law, may act as a measure of the organ’s relative efficiency. Allometric relationships were investigated to assess the heart’s efficiency concerning end-diastolic and end-systolic volumes, cardiac pressurization energy, cardiac output and mass.   Methods: Data to generate allometric relationships was obtained using a literature search, identifying heart and lung data across different mammalian and bird species. Statistical analysis was carried out using ordinary least squares (OLS) estimation.   Results: Near isometric relationships exist between body mass and seven parameters indicating no “efficiency of size” with scaling of the heart, and size-matching of the heart to the lungs and whole body. Even though there was equal efficiency in pressurization energy generation, cardiac output was maximally efficient in small mammals 
UR  - https://jtd.amegroups.org/article/view/16224