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Transcriptional programs of tumor infiltrating T-cells provide insight into mechanisms of immune response and new targets for immunotherapy

   
@article{JTD16834,
	author = {Donovan Watza and Kristen S. Purrington and Kang Chen and Ann G. Schwartz},
	title = {Transcriptional programs of tumor infiltrating T-cells provide insight into mechanisms of immune response and new targets for immunotherapy},
	journal = {Journal of Thoracic Disease},
	volume = {9},
	number = {11},
	year = {2017},
	keywords = {},
	abstract = {Early 2015 marked the first major clinical success of immunotherapy in lung cancer, resulting in the FDA approval of nivolumab (an anti-PD-1 antibody) for metastatic squamous non-small cell lung cancer (NSCLC). A little over a year later, two additional PD-1 blocking agents were approved, atezolizumab and pembrolizumab, for use in the treatment of metastatic NSCLC. Pembrolizumab was approved as a first line therapeutic option if a patient’s tumor was found to contain at least 50% of tumor cells expressing PD-L1.},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/16834}
}