@article{JTD17623,
author = {Francesco Zaraca and Maurizio Vaccarili and Gino Zaccagna and Pio Maniscalco and Giampiero Dolci and Birgit Feil and Reinhold Perkmann and Luca Bertolaccini and Roberto Crisci},
title = {Cost-effectiveness analysis of sealant impact in management of moderate intraoperative alveolar air leaks during video-assisted thoracoscopic surgery lobectomy: a multicentre randomised controlled trial},
journal = {Journal of Thoracic Disease},
volume = {9},
number = {12},
year = {2017},
keywords = {},
abstract = {Background: Intraoperative alveolar air leak (IOAAL) is one of most common complications after video-assisted thoracoscopic surgery (VATS) lobectomy. The study aimed to evaluate if, in moderate IOAAL, intraoperative polymeric biodegradable sealant (ProgelTM) reduced postoperative air leak (PAL) and consequently was cost-effective.
Methods: Patients with moderate IOAAL were randomised in a multicentre trial to intraoperative use of a sealant (Sealant group) or standard management of air leaks (Control group). Primary endpoint was the postoperative duration of air leakage. Secondary outcomes included: time to drainage removal, length of hospital stay, postoperative complications within 2 months, and cost analysis.
Results: Between January 2015 and January 2017, 255 VATS lobectomies were performed in four centres. Fifty-five met inclusion criteria and were randomly assigned to Sealant group [28] and Control group [27]. The mean air leakage duration was statistically different between groups (Sealant group =1.60 days, Control group =5.04 days; P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/17623}
}