How to cite item

Disease-free survival improved by use of adjuvant EGFR tyrosine kinase inhibitors in resectable non-small cell lung cancer: an updated meta-analysis

   
@article{JTD17842,
	author = {Yonggang Yuan and Qingyuan Huang and Chang Gu and Haiquan Chen},
	title = {Disease-free survival improved by use of adjuvant EGFR tyrosine kinase inhibitors in resectable non-small cell lung cancer: an updated meta-analysis},
	journal = {Journal of Thoracic Disease},
	volume = {9},
	number = {12},
	year = {2017},
	keywords = {},
	abstract = {Background: A previous meta-analysis of our research team suggested survival advantage from epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) after surgery in patients with EGFRmutant non-small cell lung cancer (NSCLC). This study aims to follow up on the findings of the previous one and presents our latest updates through the past few years. 
Methods: The study advanced the previous meta-analysis and included a comprehensive range of relevant studies in PubMed. Disease-free survival (DFS) with hazard ratios (HRs) was calculated using random and/ or fixed-effects models. Subgroup analysis and meta-regression analysis were also performed. 
Results: A total of 2,223 patients in seven studies were eligible for the analysis. Adjuvant EGFR-TKIs administration was significantly associated with superior DFS [HR, 0.60; 95% confidence interval (CI), 0.42–0.87], corresponding to an absolute benefit of 3.4% at 3 years, yet with significant heterogeneity (I2=80.0%, P },
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/17842}
}