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Lung cancer in connective tissue disease-associated interstitial lung disease: clinical features and impact on outcomes

   
@article{JTD18417,
	author = {Satoshi Watanabe and Keigo Saeki and Yuko Waseda and Akari Murata and Hazuki Takato and Yukari Ichikawa and Masahide Yasui and Hideharu Kimura and Yasuhito Hamaguchi and Takashi Matsushita and Kazunori Yamada and Mitsuhiro Kawano and Kengo Furuichi and Takashi Wada and Kazuo Kasahara},
	title = {Lung cancer in connective tissue disease-associated interstitial lung disease: clinical features and impact on outcomes},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {2},
	year = {2018},
	keywords = {},
	abstract = {Backgrounds: Lung cancer (LC) adversely impacts survival in patients with idiopathic pulmonary fibrosis. However, little is known about LC in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). The aim of this study was to evaluate the prevalence of and risk factors for LC in CTD-ILD, and the clinical characteristics and survival of CTD-ILD patients with LC.
Methods: We conducted a single-center, retrospective review of patients with CTD-ILD from 2003 to 2016. Patients with pathologically diagnosed LC were identified. The prevalence, risk factors, and clinical features of LC and the impact of LC on CTD-ILD patient outcomes were observed.
Results: Of 266 patients with CTD-ILD, 24 (9.0%) had LC. CTD-ILD with LC was more likely in patients who were older, male, and smokers; had rheumatoid arthritis, a usual interstitial pneumonia pattern, emphysema on chest computed tomography scan, and lower diffusing capacity of the lung carbon monoxide (DLco)% predicted; and were not receiving immunosuppressive therapy. Multivariate analysis indicated that the presence of emphysema [odds ratio (OR), 8.473; 95% confidence interval (CI), 2.241–32.033] and nonuse of immunosuppressive therapy (OR, 8.111; 95% CI, 2.457–26.775) were independent risk factors for LC. CTD-ILD patients with LC had significantly worse survival than patients without LC (10-year survival rate: 28.5% vs. 81.8%, P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/18417}
}