@article{JTD1882,
author = {Lian-Hong Li and Zhao Yu and Wen-Sen Chen and She-Lan Liu and Ye Lu and Yan-Jun Zhang and En-Fu Chen and Jun-Fen Lin},
title = {Evidence for H5 avian influenza infection in Zhejiang province, China, 2010-2012: a cross-sectional study},
journal = {Journal of Thoracic Disease},
volume = {5},
number = {6},
year = {2013},
keywords = {},
abstract = {Background: The first outbreak of H5N1 highly-pathogenic avian influenza (HPAI) virus associated with several human deaths occurred in 1997 in Hong-Kong, China. While H5N1 virus infection in poultry workers has been studied in some detail, little is known about the environmental risk factors of the H5 avian influenza virus infection in China.
Methods: A cross-sectional study was performed to evaluate the environmental load of H5 viruses in poultry-contaminated environments and to explore potential risk factors associated with infection in poultry workers between October 2010 and March 2012. Serum and environmental samples were collected in Zhejiang province, China. The hemagglutination inhibition (HI) assay was used to analyze human sera for antibodies against H5N1 virus [A/Hubei/1/2010 (H5N1) and A/Anhui/1/2005 (H5N1)]. All participants were interviewed with a standardized questionnaire to collect information on exposure to poultry. H5 Avian influenza virus in the environmental samples was detected by real time RT-PCR.
Results: One hundred and five of 3,453 environmental samples (3.0%) tested positive for H5 avian influenza virus. Fifty-five of 1,169 subjects (4.7%) tested seropositive for anti-H5N1 antibodies. A statistically significant difference in H5 virus detection rate was found among the different environments sampled (},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/1882}
}