@article{JTD19670,
author = {Zhuang-Gui Chen and Ying-Ying Li and Zhao-Ni Wang and Ming Li and Hui-Fang Lim and Yu-Qi Zhou and Liang- Ming Cai and Ya-Ting Li and Li-Fen Yang and Tian-Tuo Zhang and De-Yun Wang},
title = {Aberrant epithelial remodeling with impairment of cilia architecture in non-cystic fibrosis bronchiectasis},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {3},
year = {2018},
keywords = {},
abstract = {Background: Aberrant epithelial remodeling and/or abnormalities in mucociliary apparatus in airway epithelium contribute to infection and inflammation. It is uncertain if these changes occur in both large and small airways in non-cystic fibrosis bronchiectasis (non-CF bronchiectasis). In this study, we aim to investigate the histopathology and inflammatory profile in the epithelium of bronchi and bronchioles in bronchiectasis.
Methods: Excised lung tissue sections from 52 patients with non-CF bronchiectasis were stained with specific cellular markers and analyzed by immunohistochemistry and immunofluorescence to assess the epithelial structures, including ciliated cells and goblet cells morphology. Inflammatory cell counts and ciliary proteins expression levels of centrosomal protein 110 (CP110) and dynein heavy chain 5, axonemal (DNAH5) were assessed.
Results: Epithelial hyperplasia is found in both bronchi and bronchioles in all specimens, including hyperplasia and/or hypertrophy of goblet cells. The median cilia length is longer in hyperplastic epithelium [bronchi: 8.16 (7.03–9.14) μm, P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/19670}
}