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Transplantation of umbilical cord mesenchymal stem cells alleviates pneumonitis of MRL/lpr mice

  
@article{JTD2035,
	author = {Yanju Zhang and Yunfei Xia and Songshi Ni and Zhifeng Gu and Hua Liu},
	title = {Transplantation of umbilical cord mesenchymal stem cells alleviates pneumonitis of MRL/lpr mice},
	journal = {Journal of Thoracic Disease},
	volume = {6},
	number = {2},
	year = {2014},
	keywords = {},
	abstract = {Objective: To investigate whether the umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in the MRL/lpr mice has effect or not on their pneumonitis and the possible mechanisms underlying this treatment. 
Methods: Twenty four 18-week-old MRL/lpr female mice were divided into three groups as following: the group 2 (UC-MSCT group) have been transplanted with 1×106 UC-MSCs through caudal vein, the group 3 (multi-UC-MSCT Group) have been transplanted with 1×106 UC-MSCs three times and the group 1 (control group) have been treated with 0.5 mL phosphate buffer saline (PBS) as control. The histopathology of the lung was observed. The pulmonary expression of high mobility group box protein-1 (HMGB-1) was measured by western blot and detected by quantitation real time polymerase chain reaction (PCR). Immunohistochemistry method was used to detect HMGB-1 expressions in pulmo. 
Results: In comparision to control ground mice, UC-MSCs significantly reduced interstitial pneumonitis in the MRL/lpr mice. The lung peribronchiolar lesion index of UC-MSCT group (1.40±0.24) and multi-UC-MSCT group (1.02±0.29) were significantly decreased as compared to control group (1.95±0.35) (P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/2035}
}