@article{JTD20507,
author = {Jingxu Li and Tingting Xia and Xinguan Yang and Xiao Dong and Jiamin Liang and Nanshan Zhong and Yubao Guan},
title = {Malignant solitary pulmonary nodules: assessment of mass growth rate and doubling time at follow-up CT},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {Suppl 7},
year = {2018},
keywords = {},
abstract = {Background: The differentiation of benign and malignant solitary pulmonary nodules (SPNs), especially subsolid nodules, is still challenging because of the small size, slow growth, and atypical imaging characteristics of these nodules. We aimed to determine the significance of mass growth rate (MGR) and mass doubling time (MDT) at follow-up CT of malignant SPNs.
Methods: This retrospective study included 167 patients (169 SPNs, diameter 8–30 mm). Among the 169 SPNs, 114 malignant SPNs were classified into three types: pure ground-glass nodules (pGGNs), part-solid nodules (pSNs), and solid nodules (SNs). These patients were followed up for at least 3 months. Three-dimensional manual segmentation was performed for all these nodules, and the intra- and inter-observer variabilities of diameter, volume, and mass measurement were assessed. From initial and follow-up CT scans, growth rates of the diameter, volume, and mass of the SPNs were compared. MDT and volume doubling time (VDT) were calculated and were compared among groups.
Results: Mass measurements had the best inter-observer consistency and intra-observer repeatability; the coefficients of variation of the mass measurements were the smallest. The mean growth rates of the diameter, volume, and mass of pGGNs, pSNs, and SNs significantly differed at different time points (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/20507}
}