@article{JTD21366,
author = {Hui Shi and Jiahai Shi and Yudong Zhang and Chengqi Guan and Jun Zhu and Fei Wang and Mingming Xu and Qianqian Ju and Shu Fang and Maorong Jiang},
title = {Long non-coding RNA DANCR promotes cell proliferation, migration, invasion and resistance to apoptosis in esophageal cancer},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {5},
year = {2018},
keywords = {},
abstract = {Background: Long non-coding RNAs (lncRNAs) have important effects on the development and progression of multiple carcinomas. Our studies aimed to investigate the expression of lncRNA DANCR in esophageal squamous cell carcinoma (ESCC) tissues and paracancerous tissues, and to explore its effect on the cell biological characteristics of ESCC ECA109 cells.
Methods: The expression of DANCR was detected by qRT-PCR in human ESCC tissues and paracancerous normal tissues in ESCC patients. Small interfering RNA (siRNA) was transfected to knock down the expression of DANCR and interference efficiency was analyzed by qRT-PCR in ECA109 cells. MTT, wound healing, Transwell, TUNEL and flow cytometry (FCM) assay was used to measure the influence of DANCR on proliferation, invasion, migration and apoptosis in ECA109 cells, respectively.
Results: The expression of DANCR in ESCC tissues and ESCC cells was significantly higher compared with that in the adjacent normal tissues (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/21366}
}