@article{JTD224,
author = {Yang Ling and Jia Chen and Min Tao and Xiaoyuan Chu and Xizhi Zhang},
title = {A pilot study of nimotuzumab combined with cisplatin and 5-FU in patients with advanced esophageal squamous cell carcinoma},
journal = {Journal of Thoracic Disease},
volume = {4},
number = {1},
year = {2011},
keywords = {},
abstract = {Objective: To observe the short-term effect and adverse reaction of Nimotuzumab in combination with chemotherapy on advanced esophageal squamous cell carcinoma (ESCC).Method: 19 patients were treated with the following protocol: Nimotuzumab 400mg/time/week in the 1st week, 200mg/time/week from the 2nd to 8th week, intravenous drip (IVD); Cisplatin 80 mg/m2, IVD, 4 weeks a cycle and repeated again; 5-FU 750 mg/m2continuous 24-hours pump-in × 5 days, 4 weeks a cycle and repeated again.Result: 16 of all 19 patients can be evaluated. After treatment, RP is 42.1% (95% CI, 19.9-64.3%) and DCR is 68.4%; the main side effects include arrest of bone marrow, gastrointestinal reactions, asthenia, etc.Conclusion: Nimotuzumab in combination with cisplatin/5-FU regimens in patients with advanced ESCC is safe and effective, which deserves a further expanded sample research.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/224}
}