@article{JTD22423,
author = {Alfonso Fiorelli and Antonio D’Andrilli and Michela Bezzi and Mohsen Ibrahim and Marco Anile and Daniele Diso and Giacomo Cusumano and Alberto Terminella and Valentina Luzzi and Margherita Innocenti and Mauro Novali and Emanuele Carelli and Chiara Freda and Giovanni Natale and Valentina Peritore and Camilla Poggi and Giuseppe Failla and Marco Basile and Emilia Mazzucca and Serena Conforti and Nicola Serra and Massimo Torre and Federico Venuta and Erino Angelo Rendina and Mario Santini and Claudio Andreetti},
title = {Complications related to endoscopic lung volume reduction for emphysema with endobronchial valves: results of a multicenter study},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {Suppl 27},
year = {2018},
keywords = {},
abstract = {Background: Despite bronchoscopic lung volume reduction (BLVR) with valves is a minimally invasive treatment for emphysema, it can associate with some complications. We aimed at evaluating the rate and type of complications related to valve treatment and their impact on clinical outcomes.
Methods: It is a retrospective multicenter study including all consecutive patients with severe heterogeneous emphysema undergoing BLVR with endobronchial valve treatment and developed any complications related to this procedure. The type of complication, the time of onset, the treatment required and the out-come were evaluated. Response to treatment was assessed according to the minimal clinically important difference (MCID) as follows: an improvement of ≥15% in forced expiratory volume in one second (FEV1); of −8% in residual volume (RV); of ≥26 m in 6-minnute walking distance (6MWD); and of ≥4 points on the St. George’s Respiratory Questionnaire (SGRQ). Target lobe volume reduction (TLVR) ≥350 mL was considered significant.
Results: One hundred and seven out of 423 (25.3%) treated patients had complications related to valve treatment including pneumothorax (17.3%); pneumonia (1.7%), chronic obstructive pulmonary disease (COPD) exacerbation (0.9%), respiratory failure (1.4%), valve migration (2.1%), and hemoptysis (1.9%). In all cases complications resolved with appropriate treatment including removal of valves in 21/107 cases (19.6%). Patients with TLVR ≥350 mL (n=64) vs. those },
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/22423}
}