TY  - JOUR
AU  - Schlatzer, Christian
AU  - Bratton, Daniel J.
AU  - Schwarz, Esther I.
AU  - Gaisl, Thomas
AU  - Pepperell, Justin C. T.
AU  - Stradling, John R.
AU  - Kohler, Malcolm
PY  - 2018
TI  - Effect of continuous positive airway pressure therapy on circadian patterns of cardiac repolarization in patients with obstructive sleep apnoea: data from a randomized trial
JF  - Journal of Thoracic Disease; Vol 10, No 8 (August 29, 2018): Journal of Thoracic Disease
Y2  - 2018
KW  - 
N2  - Background: Obstructive sleep apnoea (OSA) has been proposed as an independent risk factor for sudden cardiac death (SCD). This study takes advantage of a previous randomized trial and seeks to evaluate circadian patterns of the QTc-interval, a marker of cardiac repolarization and biomarker for SCD, in patients with OSA. We hypothesized that patients with OSA would exhibit longest QTc during the night-time and that continuous positive airway pressure (CPAP) therapy would reverse this.  Methods: One hundred eighteen patients diagnosed with moderate-to-severe OSA were randomized to receive therapeutic or subtherapeutic CPAP for 4 weeks. Of these, 84 had full 24 h-Holter monitoring data at baseline and follow-up. Weighted means of all QTc-intervals were analysed over 24 h, during four time-periods (12 pm–6 am, 6 am–12 am, 12 am–6 pm, 6 pm–12 pm) as well as during each individual hour. A two-sided P value 430 ms). In these patients, CPAP led to reductions in QTc, allowing reclassification into lower risk-associated values of QTc (
UR  - https://jtd.amegroups.org/article/view/22719