@article{JTD22915,
author = {Peiyan Zheng and Xiaoqing Liu and Huimin Huang and Zijun Guo and Ge Wu and Haisheng Hu and Chuanxu Cai and Wenting Luo and Nili Wei and Qian Han and Baoqing Sun},
title = {Diagnostic value of KL-6 in idiopathic interstitial pneumonia},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {8},
year = {2018},
keywords = {},
abstract = {Background: Idiopathic interstitial pneumonia (IIP) can induce type II alveolar epithelial cell proliferation and pulmonary basement membrane damage and subsequent release of Krebs von den Lungen-6 antigen (KL-6) to the bloodstream. This study investigated the diagnostic and prognostic value of serum KL-6 levels for IIP.
Methods: One hundred five patients with lung disease were divided into IIP (n=75) and non-IIP groups (n=30) according to pathological and computed tomography findings. Serum KL-6 levels were evaluated in blood samples from all subjects. Nineteen IIP group patients were also subjected to a longitudinal study of disease progression and serum KL-6 levels over time.
Results: Serum KL-6 levels were significantly higher in the IIP group vs. the non-IIP group [1,096.0 (565.0–1,544.0) vs. 226.0 (173.5–346.5) U/mL; P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/22915}
}