%0 Journal Article
%T Diagnostic value of KL-6 in idiopathic interstitial pneumonia
%A Zheng, Peiyan
%A Liu, Xiaoqing
%A Huang, Huimin
%A Guo, Zijun
%A Wu, Ge
%A Hu, Haisheng
%A Cai, Chuanxu
%A Luo, Wenting
%A Wei, Nili
%A Han, Qian
%A Sun, Baoqing
%J Journal of Thoracic Disease
%D 2018
%B 2018
%9 
%! Diagnostic value of KL-6 in idiopathic interstitial pneumonia
%K 
%X Background: Idiopathic interstitial pneumonia (IIP) can induce type II alveolar epithelial cell proliferation and pulmonary basement membrane damage and subsequent release of Krebs von den Lungen-6 antigen (KL-6) to the bloodstream. This study investigated the diagnostic and prognostic value of serum KL-6 levels for IIP.  Methods: One hundred five patients with lung disease were divided into IIP (n=75) and non-IIP groups (n=30) according to pathological and computed tomography findings. Serum KL-6 levels were evaluated in blood samples from all subjects. Nineteen IIP group patients were also subjected to a longitudinal study of disease progression and serum KL-6 levels over time.   Results: Serum KL-6 levels were significantly higher in the IIP group vs. the non-IIP group [1,096.0 (565.0–1,544.0) vs. 226.0 (173.5–346.5) U/mL; P
%U https://jtd.amegroups.org/article/view/22915
%V 10
%N 8
%P 4724-4732
%@ 2077-6624