@article{JTD24310,
author = {Hideaki Yamakawa and Eri Hagiwara and Tae Iwasawa and Ryota Otoshi and Erina Tabata and Satoshi Ikeda and Ryo Okuda and Tomohisa Baba and Shinichiro Iso and Koji Okudela and Tamiko Takemura and Shinji Sato and Takashi Ogura},
title = {Interstitial lung disease associated with anti-citrullinated peptide/ protein antibody-positive anti-synthetase syndrome},
journal = {Journal of Thoracic Disease},
volume = {10},
number = {10},
year = {2018},
keywords = {},
abstract = {Little has been reported on the characteristics of interstitial lung disease (ILD) associated with anti-citrullinated peptide/protein antibody (ACPA)-positive anti-synthetase syndrome (ASS). We sought to investigate the clinical, radiologic, and pathologic features of patients with ILD associated with ACPA-positive ASS. Medical records of seven ILD patients with positive results of both ACPA and anti-aminoacyl-tRNA synthetase antibody were retrospectively reviewed. Five patients had clinical symptoms associated with ASS other than ILD. On high-resolution computed tomography (HRCT) analysis, a nonspecific interstitial pneumonia (NSIP) pattern was shown in 3 patients and NSIP with organizing pneumonia (OP) overlap in 2 patients. Coronal slices of these 5 patients showed lower lung disease predominance with traction caudally on major fissures due to lower lobe volume loss. These were features that could commonly be observed in ASS-associated ILD. Pathological findings available for 3 patients showed NSIP. The characteristics of ILD associated with ACPA-positive ASS appear to be similar to those of ILD associated with ASS, but not to rheumatoid arthritis (RA) or ACPA, especially in terms of the radiological findings.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/24310}
}