@article{JTD2457,
author = {Tülay Dal and Hilal Sazak and Mehtap Tunç and Şaziye Şahin and Aydın Yılmaz},
title = {A comparison of ketamine-midazolam and ketamine-propofol combinations used for sedation in the endobronchial ultrasoundguided transbronchial needle aspiration: a prospective, singleblind, randomized study},
journal = {Journal of Thoracic Disease},
volume = {6},
number = {6},
year = {2014},
keywords = {},
abstract = {Objective: We aimed to compare the effectiveness and safety of ketamine-midazolam and ketaminepropofol combinations for procedural sedation in endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA).
Methods: Sixty patients who were undergoing EBUS-TBNA were included in this study. Patients were randomly divided into two groups. Group 1 was given 0.25 mg/kg intravenous (iv) ketamine, 2 min later than 0.05 mg/kg iv midazolam. Group 2 received 0.125 mg/kg ketamine-propofol mixture (ketofol), 2 min subsequent to injection of 0.25 mg/kg each. Sedation was maintained with additional doses of ketamine 0.25 mg/kg, and ketofol 0.125 mg/kg each in Group 1 and Group 2, respectively. Blood pressure, heart rate (HR), peripheral oxygen saturation, respiratory rate (RR), Ramsay Sedation Score (RSS), and severity of cough were recorded prior to and after administration of sedation agent in the beginning of fiberoptic bronchoscopy (FOB) and every 5 min of the procedure. The consumption of the agents, the satisfactions of the bronchoscopist and the patients, and the recovery time were also recorded.
Results: HR in the 10th min and RSS value in the 35th min of induction in Group 1 were higher than the other group (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/2457}
}