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Distribution of the atypical pathogens of community-acquired pneumonia to disease severity

   
@article{JTD25110,
	author = {Cheng Gong and Tiegang Zhang and Ming Luo and Aihua Li and Mei Dong and Maozhong Li and Yiting Wang and Fang Huang},
	title = {Distribution of the atypical pathogens of community-acquired pneumonia to disease severity},
	journal = {Journal of Thoracic Disease},
	volume = {10},
	number = {11},
	year = {2018},
	keywords = {},
	abstract = {Background: To investigate the epidemiological characteristics of 11 atypical pathogens of community-acquired pneumonia (CAP) among Chinese, and to determine whether or not there is an association between these pathogens and the severity of illness.
Methods: We conducted a surveillance study for CAP in 30 hospitals of Beijing. Epidemiological data and clinical specimens were systematically collected from enrolled CAP patients. The detection for 11 atypical pathogens [9 respiratory viruses, Mycoplasma pneumoniae (MP) and Chlamydophila pneumoniae (CP)] was performed. Risk factors of severe CAP and death in Hospital were evaluated. 
Results: A total of 6,008 CAP patients [including 1,071 severe CAP (SCAP)] were enrolled. The overall detection rate of the 11 atypical pathogens was 42.4% among 1,925 child CAP (39.9% among 274 child SCAP), and 25.8% among 4,083 adult CAP (22.8% among 797 adult SCAP). The most frequent atypical pathogen among child SCAP was parainfluenza virus (10.2%) followed by respiratory syncytial virus (RSV) (8.4%). However, the most frequent atypical pathogen among adult SCAP was influenza virus (8.9%) followed by parainfluenza virus (3.8%). Multivariate analyses showed that the important predictors for SCAP were an age ≤9 years, an age ≥65 years and co-existing diseases. These factors, except an age ≤9 years, were also predictors of death in Hospital. None of these 11 atypical pathogens was included as the risk factors of SCAP or death in Hospital.
Conclusions: Although these 11 atypical pathogens were the common causes of CAP (including SCAP) among Chinese, they were not observed to increase risks for SCAP or death in Hospital.},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/25110}
}