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The upregulated expression of OX40/OX40L and their promotion of T cells proliferation in the murine model of asthma

  
@article{JTD2841,
	author = {Wei Lei and Da-Xiong Zeng and Can-Hong Zhu and Gao-Qin Liu and Xiu-Qin Zhang and Chang-Guo Wang and Qin Wang and Jian-An Huang},
	title = {The upregulated expression of OX40/OX40L and their promotion of T cells proliferation in the murine model of asthma},
	journal = {Journal of Thoracic Disease},
	volume = {6},
	number = {7},
	year = {2014},
	keywords = {},
	abstract = {Objective: To investigate whether the expression of OX40/OX40 ligand (OX40L) was upregulated in a murine model of asthma and their significance in the pathogenesis of asthma. 
Methods: After an ovalbumin-sensitized/challenged murine model of asthma was established, the expressions of OX40, OX40L in peripheral blood mononuclear cells (PBMCs) and bronchoalveolar lavage fluid (BALF) cell pellets were measured. Then T cell proliferation was analyzed by cell counting kit-8, and the protein levels of OX40 and OX40L in the lungs were determined by immunohistochemistry. The concentrations of IL-4 and IFN-γ in BALF and T cell culture supernatant were evaluated by ELISA. 
Results: The percentages of CD4+OX40+, CD19+OX40L+, F4/80+OX40L+ in PBMCs and BALF cell pellets were higher in asthma group than in control group (all P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/2841}
}