@article{JTD2898,
author = {Wen-Xiao Ding and Yan-Bin Dong and Ning Ding and Xiao-Feng Zhang and Shi-Jiang Zhang and Xi-Long Zhang and Jian-Nan Liu and Gan Lu},
title = {Adiponectin protects rat heart from left ventricular remodeling induced by chronic intermittent hypoxia via inhibition of TGF-β/smad2/3 pathway},
journal = {Journal of Thoracic Disease},
volume = {6},
number = {9},
year = {2014},
keywords = {},
abstract = {Objective: Obstructive sleep apnea syndrome (OSAS) is associated with many cardiovascular disorders. Chronic intermittent hypoxia (CIH) is the primary player in OSAS of the many associated factors. This study was in order to investigate the effects of the Adiponectin (Ad) on left ventricular remodeling induced by CIH.
Methods: Forty-five rats were randomly divided into three groups: normal control (NC) group, CIH group and CIH plus Ad supplemented (CIH + Ad) group. After 35 days’ CIH exposure, masson analysis was used to detect the left ventricular fibrosis and western blot was used to measure the protein expression of collagen I, collagen III and TGF-β/smad2/3 pathway. Gene analysis by RT-PCR was used to study the MMP2 and TIMP2.
Results: After CIH exposure, the fibrosis of left ventricular in CIH group was significantly remarkable than that in both NC and CIH + Ad groups (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/2898}
}