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Low versus high pulse oxygen saturation directed oxygen therapy in critically ill patients: a randomized controlled pilot study

  
@article{JTD32731,
	author = {Xiaobo Yang and You Shang and Shiying Yuan},
	title = {Low versus high pulse oxygen saturation directed oxygen therapy in critically ill patients: a randomized controlled pilot study},
	journal = {Journal of Thoracic Disease},
	volume = {11},
	number = {10},
	year = {2019},
	keywords = {},
	abstract = {Background: Data on the safety and feasibility of pulse oxygen saturation (SpO2) directed oxygen therapy in mainland China are scarce. The aim of this pilot study was to test the feasibility of SpO2 directed oxygen therapy and to calculate sample size base on differences in 28-day mortality rates for a large sample-sized randomized trial.
Methods: This prospective pilot study enrolled 214 adult patients with an expected intensive care unit (ICU) stay of more than 72 hours. Patients were randomized into a low SpO2 group (SpO2 90–95%) or high SpO2 group (SpO2 96–100%). The primary outcome was 28-day mortality.
Results: One hundred patients were included in the low SpO2 group, and 114 patients were included in the high SpO2 group. The demographic and baseline characteristics were not different. The time-weighted SpO2 average was significantly lower in the low SpO2 group than in the high SpO2 group [mean ± standard deviation (SD), 95.7%±2.3% vs. 98.2%±1.8%, P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/32731}
}