TY  - JOUR
AU  - Hamzaoui, Olfa
AU  - Shi, Rui
PY  - 2020
TI  - Early norepinephrine use in septic shock
JF  - Journal of Thoracic Disease; Vol 12, Supplement 1 (February 01, 2020): Journal of Thoracic Disease (Sepsis: Science and Fiction)
Y2  - 2020
KW  - 
N2  - As vascular tone depression is a hallmark of septic shock, administration of norepinephrine is logical in this setting. In this article, we provide and develop the following arguments for an early use of norepinephrine—the recommended first-line vasopressor—in septic shock: (I) prevention of prolonged severe hypotension, (II) increase in cardiac output through an increase in cardiac preload and/or contractility, (III) improvement of microcirculation and tissue oxygenation, (IV) prevention of fluid overload, and (V) improvement of outcome. Presence of a low diastolic arterial pressure as a marker of depressed vascular tone can be used as a trigger to initiate norepinephrine urgently.
UR  - https://jtd.amegroups.org/article/view/34842