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Sodium tanshinone IIA silate as an add-on therapy in patients with unstable angina pectoris

  
@article{JTD3617,
	author = {Haiyan Zhang and Mingzhi Long and Zhiwen Wu and Xu Han and Yichao Yu},
	title = {Sodium tanshinone IIA silate as an add-on therapy in patients with unstable angina pectoris},
	journal = {Journal of Thoracic Disease},
	volume = {6},
	number = {12},
	year = {2014},
	keywords = {},
	abstract = {Objective: To investigate whether sodium tanshinone IIA silate (STS) as an add-on therapy to conventional treatment may provide additional benefits for patients with unstable angina pectoris (UAP) and is associated with changes in profiles of serum inflammatory factors. 
Methods: Eighty patients diagnosed with UAP were randomly divided into two groups for the 2-week treatment. The control group received conventional therapy, while the treatment group was given intravenous STS (0.06 mg in 250 mL, once daily) as an add-on therapy to the conventional medications. The therapeutic efficacy and changes in serum levels of several inflammatory cytokines, including monocyte chemotactic protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α), peroxisome proliferator-activated receptor (PPAR-γ), and high-sensitivity C-reactive protein (hs-CRP) from baseline were determined and compared between the two group. 
Results: The clinical symptoms of all patients in both groups were improved after treatment. The overall rate of effectiveness was 97.5% in the treatment group vs. 80.0% in the control group. Serum levels of MCP-1, TNF-α, and hs-CRP levels were significantly reduced in both groups (P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/3617}
}