@article{JTD3692,
author = {Xi Chen and Lizhu Zhang and Tong Su and Heng Li and Qiang Huang and Dan Wu and Chengjian Yang and Zhijun Han},
title = {Kinetics of plasma microRNA-499 expression in acute myocardial infarction},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {5},
year = {2015},
keywords = {},
abstract = {Background: MicroRNA (miRNA) is reported to be present in human plasma and has been increasingly suggested as a biomarker for diseases. Our study aimed to investigate the kinetics of cardiac-specific microR-499 (miR-499) in acute myocardial infarction (AMI).
Methods: Circulating concentrations of cardiac enriched miR-499 were measured by quantitative PCR in 73 patients with acute coronary syndrome (ACS), including 53 with AMI and 20 with unstable angina (UA). Thirty healthy subjects were used as controls. Plasma samples in AMI group were obtained immediately after admission and at 12 h, 24 h, 3 d and 7 d after onset of symptoms. Plasma samples in UA and healthy control groups were collected immediately after admission. The severity and extent of coronary stenotic lesions were evaluated on the basis of coronary angiography using Gensini score.
Results: miR-499 expression levels were significantly higher in the 53 AMI patients than in the 20 UA patients and 30 healthy controls immediately after admission (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/3692}
}