@article{JTD3848,
author = {Charalampos Charalampidis and Andrianna Youroukou and George Lazaridis and Sofia Baka and Ioannis Mpoukovinas and Vasilis Karavasilis and Ioannis Kioumis and Georgia Pitsiou and Antonis Papaiwannou and Anastasia Karavergou and Kosmas Tsakiridis and Nikolaos Katsikogiannis and Eirini Sarika and Konstantinos Kapanidis and Leonidas Sakkas and Ipokratis Korantzis and Sofia Lampaki and Konstantinos Zarogoulidis and Paul Zarogoulidis},
title = {Physiology of the pleural space},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {Suppl 1},
year = {2015},
keywords = {},
abstract = {The pleural cavity is created between the 4th and 7th week of embryologic development. These embryonic components of visceral and parietal pleurae develop different anatomic characteristics with regard to vascular, lymphatic, and nervous supply. There are two layers: a superficial mesothelial cell layer facing the pleural space and an underlying connective tissue layer. The pleura might present inflammatory response and maintenance of the pleural fluid is observed. The latter function is especially important in the mechanical coupling of the lung and chest wall. Fluid is filtered into the pleural space according to the net hydrostatic oncotic pressure gradient. It flows downward along a vertical pressure gradient, presumably determined by hydrostatic pressure and resistance to viscous flow. There also may be a net movement of fluid from the costal pleura to the mediastinal and interlobar regions. In these areas, pleural fluid is resorbed primarily through lymphatic stomata on the parietal pleural surface. In the current review we will present the physiology of the pleural space in a step by step manner.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/3848}
}