@article{JTD4226,
author = {Wei-Jie Guan and Yong-Hua Gao and Gang Xu and Zhi-Ya Lin and Yan Tang and Hui-Min Li and Zhi-Min Li and Jin-Ping Zheng and Rong-Chang Chen and Nan-Shan Zhong},
title = {Effect of airway Pseudomonas aeruginosa isolation and infection on steady-state bronchiectasis in Guangzhou, China},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {4},
year = {2015},
keywords = {},
abstract = {Background: Current status of Pseudomonas aeruginosa (PA) infection in clinically stable bronchiectasis in mainland China remains unclear. Objectives: To compare the inflammation and lung function impairment in bronchiectasis patients isolated or infected with PA, potentially pathogenic microorganisms (PPMs) and commensals, and to identify factors associated with PA isolation and infection.
Methods: Patients with steady-state bronchiectasis and healthy subjects were recruited. Peripheral blood and sputum were sampled to determine inflammatory markers and bacterial loads in steady-state bronchiectasis and health. Spirometry and diffusing capacity were also measured.
Results: We enrolled 144 bronchiectasis patients and 23 healthy subjects. PA isolation and infection accounted for 44 and 39 patients, who demonstrated significant inflammatory responses and markedly impaired spirometry, but not diffusing capacity, compared with healthy subjects and patients isolated with other PPMs and commensals (all P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/4226}
}