@article{JTD4259,
author = {Xin Chen and Ying-Bo Kang and Li-Qing Wang and Yun Li and Yu-Wen Luo and Zhe Zhu and Rui Chen},
title = {Addition to inhaled corticosteroids of leukotriene receptor antagonists versus theophylline for symptomatic asthma: a meta-analysis},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {4},
year = {2015},
keywords = {},
abstract = {Background: Inhaled corticosteroids (ICSs) are widely used in combination with second controller medications in the management of asthma in adults and children. There lacks a systematic comparison between addition of leukotriene receptor antagonists (LTRAs) and theophylline to ICS. The purpose of this meta-analysis was to evaluate the difference of the efficacy and safety profile of adding either LTRAs or theophylline to ICS in adults and children with symptomatic asthma.
Methods: Randomised controlled trials (RCTs) published prior to November 2014 were acquired through systematically searching and selected based on the established inclusion criteria for publications. The data extracted from the included studies were further analyzed by a meta-analysis.
Results: We included eight RCTs, of which six recruited adults and two recruited children aged 5 to 14 years. The primary outcomes were changes in lung function from baseline, including forced expiratory volume in the first second (FEV1) and peak expiratory flow (PEF). Overall, addition of LTRAs led to significantly better morning PEF \{mean difference (MD) 16.94 [95% confidence interval (CI): 11.49- 22.39] L/min, P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/4259}
}