@article{JTD4453,
author = {Yun-En Lin and Qi-Nian Wu and Xiao-Dong Lin and Guang-Qiu Li and Ya-Jie Zhang},
title = {Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {5},
year = {2015},
keywords = {},
abstract = {Background: Paired basic amino acid-cleaving enzyme 4 (PACE4) was shown to enhance tumor cells proliferation and invasive. This study provides the first investigation of PACE4 expression in non-small cell lung cancer (NSCLC) and the correlation with clinicopathologic features, prognostic indicators of 172 cases.
Methods: Quantitative real-time PCR (RT-PCR) and immunofluorescence (IF) were applied to detect PACE4 expression in NSCLC and 16HBE cell lines, then 172 consecutive NSCLC and 15 normal lung tissues were studied through immunohistochemistry (IHC). The association between PACE4 expression and clinicopathological parameters was evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of PACE4 expression on survival.
Results: PACE4 expression in NSCLC were significantly higher than normal lung cell and tissues (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/4453}
}