@article{JTD4476,
author = {Wen-Zhao Zhong and Wei Li and Xue-Ning Yang and Ri-Qiang Liao and Qiang Nie and Song Dong and Hong-Hong Yan and Xu-Chao Zhang and Hai-Yan Tu and Bin-Chao Wang and Jian Su and Jin-Ji Yang and Qing Zhou and Yi-Long Wu},
title = {Accidental invisible intrathoracic disseminated pT4-M1a: a distinct lung cancer with favorable prognosis},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {7},
year = {2015},
keywords = {},
abstract = {Objective: In the 7th edition of the TNM classification of malignant tumors, the prognosis for pT4- M1a stage IV lung cancer is better than for stage pIIIB. Subgroups of lung cancer patients who underwent incomplete resection (R1/R2) have a favorable prognosis. This study compares the prognosis between cases of invisible local residual disease and intrathoracic disseminated pT4-M1aIV.
Methods: Patient characteristics and histological and molecular profiles were retrospectively collected for lung cancer patients who underwent resection intended to be curative but were accidentally incomplete. All patients were divided into either a local residual group or an intrathoracic disseminated pT4M1a group. Progression-free survival (PFS) and overall survival (OS) were evaluated by Kaplan-Meier and Cox regression models.
Results: In total, 1,483 consecutive lung cancer patients receiving thoracotomies at Guangdong Lung Cancer Institute were retrospectively analyzed. Fifty-eight patients receiving incomplete resections (R1/ R2) were enrolled, including 38 patients with local residual cancer (2.6% of all patients) and 20 patients with disseminated pM1a (1.3%). Patient characteristics, and histological and molecular profiles of the two groups were different. Compared to the local residual group, the disseminated pT4-M1a group contained more females (P=0.002), more patients younger than 60 years of age (P=0.028), more non-smokers (P=0.037), more adenocarcinomas (20/20 vs. 20/38, P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/4476}
}