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Clarithromycin might attenuate the airway inflammation of smoke-exposed asthmatic mice via affecting HDAC2

   
@article{JTD4570,
	author = {Min Hao and Jiangtao Lin and Jun Shu and Xiaoyan Zhang and Qiongzhen Luo and Lin Pan and Jing Guo},
	title = {Clarithromycin might attenuate the airway inflammation of smoke-exposed asthmatic mice via affecting HDAC2},
	journal = {Journal of Thoracic Disease},
	volume = {7},
	number = {7},
	year = {2015},
	keywords = {},
	abstract = {Background: Smoke has been proved to be one of the most dangerous ingredients leading to the unsatisfying treatment response of asthmatics to inhaled corticosteroids (ICS) therapy. Macrolides, a class of antibiotics, possess the traits of immunomodulation and anti-inflammation besides antimicrobial activity. Given that studies on the efficacy of macrolides on the refractory asthma patient have diverting conclusions, this article was carried on to investigate the effects of macrolide on the airway inflammation of smoke-exposed asthmatic mice.
Methods: BALB/c mice were chosen to be the subjects of this study. They were raised to establish asthma model (OVA group); and one asthma group were exposed to the smoke (SEA group), one asthma group were treat with clarithromycin (CAM group) after smoke exposure. Control group mice were used as parallel comparison. Total inspiratory resistance (RL), expiratory resistance of the lung (Re) and lung compliance (Cdyn) were the main index to evaluate airway hyperresponsiveness (AHR). The histopathological change was studied to assess lung tissue inflammation. Cell counts in bronchoalveolar lavage fluid (BALF) were also tested to represent airway inflammation. IL-4 and CXCL1 in BALF and serum were also used to evaluate the airway inflammation. Histone deacelytase2 (HDAC2) activity of lung tissues was measure by assay kit. HDAC2 expression in the lung tissue had been detected by western blot.
Results: Re, RL and Cdyn were monitored to represent airway responsiveness. All of the three indicators in SEA group were significantly different from control group, while clarithromycin improved airway responsiveness and the three indicator were statistically significant (P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/4570}
}