@article{JTD5068,
author = {Qi Liu and Yong-Hua Gao and Dong-Ming Hua and Wen Li and Zhe Cheng and Hui Zheng and Rong-Chang Chen},
title = {Functional residual capacity in beagle dogs with and without acute respiratory distress syndrome},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {8},
year = {2015},
keywords = {},
abstract = {Background: Traditionally, the choice of tidal volume for mechanical ventilation was based on body weight (BW) and usually, predicted BW was used to correct actual BW inter-individual variations in obesity and muscle weight. The method of selecting tidal volume depended on the fact that normal lung volumes, especially functional residual capacity (FRC), were mainly determined by height (indirectly by predicted BW), sex and age in healthy persons. However, FRCs in patients with acute respiratory distress syndrome (ARDS) might not abide by the same rule and be significantly different from each other in patients with the same height and sex. We hypothesized that FRC was determined by body length (surrogate for predicted BW) and age in healthy male beagle dogs but not in lung injured ones.
Methods: A total of 24 dogs were recruited and ARDS model was induced by intravenous injection of oleic acid. FRC was measured by chest computer tomography. Blood gas analysis, extra vascular lung water and respiratory system mechanics were tested at baseline and post-lung injury. Age, body length and actual BW were also recorded before experiments.
Results: After lung injury, FRC decreased sharply from baseline (414±84) to (214±70) mL. For healthy lungs, FRC could be estimated by the following formula: FRC =21.86 × age (months) + 20.55 × body length (cm) – 1,337.98 (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/5068}
}