@article{JTD5757,
author = {Shuang-Jiang Li and Da-Li Chen and Wen-Biao Zhang and Cheng Shen and Guo-Wei Che},
title = {Prognostic value of stromal decorin expression in patients with breast cancer: a meta-analysis},
journal = {Journal of Thoracic Disease},
volume = {7},
number = {11},
year = {2015},
keywords = {},
abstract = {Background: Numbers of studies have investigated the biological functions of decorin (DCN) in oncogenesis, tumor progression, angiogenesis and metastasis. Although many of them aim to highlight the prognostic value of stromal DCN expression in breast cancer, some controversial results still exist and a consensus has not been reached until now. Therefore, our meta-analysis aims to determine the prognostic significance of stromal DCN expression in breast cancer patients.
Methods: PubMed, EMBASE, the Web of Science and China National Knowledge Infrastructure (CNKI) databases were searched for full-text literatures met out inclusion criteria. We applied the hazard ratio (HR) with 95% confidence interval (95% CI) as the appropriate summarized statistics. Q-test and I2 statistic were employed to estimate the level of heterogeneity across the included studies. Sensitivity analysis was conducted to further identify the possible origins of heterogeneity. The publication bias was detected by Begg’s test and Egger’s test.
Results: There were three English literatures (involving 6 studies) included into our meta-analysis. On the one hand, both the summarized outcomes based on univariate analysis (HR: 0.513; 95% CI: 0.406-0.648; P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/5757}
}