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Dacomitinib, an emerging HER-targeted therapy for non-small cell lung cancer

   
@article{JTD586,
	author = {Richard L. Carpenter and Hui-Wen Lo},
	title = {Dacomitinib, an emerging HER-targeted therapy for non-small cell lung cancer},
	journal = {Journal of Thoracic Disease},
	volume = {4},
	number = {6},
	year = {2012},
	keywords = {},
	abstract = {Lung cancer is the leading cause of cancer-related mortality worldwide. As much as 85% of primary lung cancers are non-small cell lung cancers (NSCLC) (1). A major characteristic of NSCLC is aberrant signaling pathways, including those mediated by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases, HER1 (epidermal growth factor receptor; EGFR), HER2, HER3 and HER4. At least one member of the HER family of receptors are expressed in 90% of solid tumors with 60% of these tumors containing abnormalities in a HER family member contributing to tumor development (2).},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/586}
}