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Initial synchronized intermittent mandatory ventilation versus assist/control ventilation in treatment of moderate acute respiratory distress syndrome: a prospective randomized controlled trial

   
@article{JTD6186,
	author = {Jian Luo and Mao-Yun Wang and Bin-Miao Liang and He Yu and Fa-Ming Jiang and Ting Wang and Chao-Li Shi and Pei-Jun Li and Dan Liu and Xiao-Ling Wu and Zong-An Liang},
	title = {Initial synchronized intermittent mandatory ventilation versus assist/control ventilation in treatment of moderate acute respiratory distress syndrome: a prospective randomized controlled trial},
	journal = {Journal of Thoracic Disease},
	volume = {7},
	number = {12},
	year = {2015},
	keywords = {},
	abstract = {Background: Assist/control (A/C) ventilation may induce delirium in patients with acute respiratory distress syndrome (ARDS). We conducted a trial to determine whether initial synchronized intermittent mandatory ventilation with pressure support (SIMV + PS) could improve clinical outcomes in these patients.
Methods: Intubated patients with moderate ARDS were enrolled and we compared SIMV + PS with A/C. Identical sedation, analgesia and ventilation strategies were performed. The co-primary outcomes were early (≤72 h) partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2/FiO2) and incidence of delirium. The secondary outcomes were all-cause in-hospital mortality, dosages of analgesics and sedatives, incidence of patient-ventilator asynchrony, and duration of mechanical ventilation and hospital stay.
Results: We screened 2,684 patients and 40 patients were enrolled in our study. In SIMV + PS, early (≤72 h) PaO2/FiO2 was greater improved than that at baseline and that in A/C (P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/6186}
}