%0 Journal Article %T Years of sorafenib investigation in advanced non-small cell lung cancer: is there a ‘NExUS’ linking an unsuccessful treatment and a potentially active one? %A Metro, Giulio %A Minotti, Vincenzo %A Crinò, Lucio %J Journal of Thoracic Disease %D 2012 %B 2012 %9 %! Years of sorafenib investigation in advanced non-small cell lung cancer: is there a ‘NExUS’ linking an unsuccessful treatment and a potentially active one? %K %X Sorafenib, a multi-targeted receptor tyrosine-kinase inhibitor (TKI) with a supposedly predominant anti-angiogenic activity (inhibition of vascular endothelial growth factor receptor-2, -3 and platelet-derived growth factor ß), has been the subject of extensive clinical research in advanced non-small cell lung cancer (NSCLC). %U https://jtd.amegroups.org/article/view/625 %V 4 %N 6 %P 635-638 %@ 2077-6624