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High-resolution CT findings of patients with pulmonary nocardiosis

	author = {Naoki Tsujimoto and Takeshi Saraya and Ken Kikuchi and Saori Takata and Yasuyuki Kurihara and Sayuki Hiraoka and Hiroshi Makino and Shota Yonetani and Koji Araki and Haruyuki Ishii and Hajime Takizawa and Hajime Goto},
	title = {High-resolution CT findings of patients with pulmonary nocardiosis},
	journal = {Journal of Thoracic Disease},
	volume = {4},
	number = {6},
	year = {2012},
	keywords = {},
	abstract = {Background: Opportunistic pulmonary infection with Nocardia species is rare in humans, and only a few studies have radiologically analyzed patients with pulmonary nocardiosis using high-resolution computed tomography (HRCT).
Methods: We retrospectively reviewed the medical records of patients with pulmonary nocardiosis at our hospital between April 2006 and December 2011 to assess HRCT and clinical findings. We also searched the medical literature for pulmonary nocardiosis reported in Japan between 2002 and 2011 for comparison.
Results: We identified seven patients at our institution and 33 reported infections in Japan. Four of our patients were immunocompetent, whereas the other three had impaired cellular immunity due to type 2 diabetes mellitus or having been inappropriately treated with steroid. Thoracic HRCT revealed no zonal predominance, but tropism for distribution from the middle to the peripheral area, and radiological findings of nodules, cavitation, mass, consolidations, bronchial wall thickening, septal line thickening and ground glass opacity (GGO) were evident. The main HRCT finding in our study comprised nodules (n=5, 71.4%) <30 mm and four patients had multiple nodules as described in other reports. Furthermore, we discovered a crazy paving appearance (CPA) around nodules, cavities, masses or consolidations in five patients (71.4%).
Conclusions: Multiple nodules distributed from the middle to the peripheral area on HRCT might reflect pulmonary nocardiosis, and CPA seemed to be a worth paying attention to the diagnosis.},
	issn = {2077-6624},	url = {}