@article{JTD638,
author = {Shao-Yong Gao and Jian-Qiang Huang and Yi-Feng Luo and Zhi-Ping Li and Can-Mao Xie and Yu-Biao Guo},
title = {Comparison of the lung function change in patients with COPD and bronchial asthma before and after treatment with budesonide/formoterol},
journal = {Journal of Thoracic Disease},
volume = {4},
number = {6},
year = {2012},
keywords = {},
abstract = {Objective: This study investigated the rapid onset of bronchodilation effect and compared lung function changes following budesonide/formoterol (Symbicort Turbuhaler®) inhalation in Chinese patients with moderate-severe chronic obstructive pulmonary disease (COPD) and bronchial asthma.
Methods: In this open-label, parallel-group clinical study, patients eligible for study were divided into COPD group (n=62, mean age 68.16±8.75 years) and asthma group (n=30, mean age 45.80±12.35 years). Lung function tests (include FEV1, FVC, FEV1/FVC, and IC) were performed at baseline (t=0 min time point, value before inhalation of budesonide/ formoterol), and then eligible patients received two inhalations of budesonide/formoterol (160/4.5 μg). Lung function tests were reassessed at t=3, 10 and 30 min time point. The primary end-point was lung function change 3 min after drug inhalation, and the secondary end-points were comparison of the gas flow rate (ΔFEV1) and volume responses (ΔFVC, ΔIC) between COPD and asthma patients after inhalation of budesonide/formoterol.
Results: Compared with the baseline, all patients significantly improved their lung function (included FEV1, FVC, FEV1/ FVC, and IC) at 3 min (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/638}
}