TY  - JOUR
AU  - Mezidi, Mehdi
AU  - Guérin, Claude
PY  - 2016
TI  - Conservative versus liberal oxygenation targets for mechanically ventilated patients—a pilot multicenter randomized controlled trial
JF  - Journal of Thoracic Disease; Vol 8, No 3 (March 18, 2016): Journal of Thoracic Disease
Y2  - 2016
KW  - 
N2  - Panwar and colleagues recently reported the results of a prospective multicenter international interventional trial comparing two oxygenation targets in all-comer patients receiving invasive mechanical ventilation in ICU, namely a conservative (SpO2 88–92%) versus a liberal target (≥96%), by accommodating FIO2 (1). The rationale behind this was that no previous trial was done to compare different oxygenation goals in mechanically ventilated patients. Even though oxygen therapy is frequently used in the critical care setting, its goals are not well defined. The primary outcome was the area under curve of transcutaneous oxygen saturation (SpO2). They included 104 patients in both groups and found that the primary end-point was significantly lower in the conservative than in the liberal group. From this result the authors concluded that reaching a conservative oxygenation target is feasible, which will serve for an upcoming large trial testing these two oxygenation levels.
UR  - https://jtd.amegroups.org/article/view/6769